Preparation and Cytotoxic Activity of Some New Rhodomycin Derivatives Bearing Modifications in the Sugar Moiety

NECTARIOS ALIGIANNIS; NICOLE POULI; PANAGIOTIS MARAKOS; ALEXIOS-LEANDROS SKALTSOUNIS; JEAN-CLAUDE FLORENT; ELISABETH M. PERCHELLET; BONNIE J. SPERFSLAGE; CORBIN J. McILVAIN; JEAN-PIERRE PERCHELLET

doi:10.7164/antibiotics.55.181

NECTARIOS ALIGIANNIS, NICOLE POULI, PANAGIOTIS MARAKOS, ALEXIOS-LEANDROS SKALTSOUNIS, JEAN-CLAUDE FLORENT, ELISABETH M. PERCHELLET, BONNIE J. SPERFSLAGE, CORBIN J. McILVAIN, JEAN-PIERRE PERCHELLET

Author information

NECTARIOS ALIGIANNIS
University of Athens, Department of Pharmacy, Division of Pharmacognosy
NICOLE POULI
University of Athens, Department of Pharmacy, Division of Pharmaceutical Chemistry
PANAGIOTIS MARAKOS
University of Athens, Department of Pharmacy, Division of Pharmaceutical Chemistry
ALEXIOS-LEANDROS SKALTSOUNIS
University of Athens, Department of Pharmacy, Division of Pharmacognosy
JEAN-CLAUDE FLORENT
UMR 176 CNRS/Institut Curie, Section Recherche
ELISABETH M. PERCHELLET
Kansas State University, Anti-Cancer Drug Laboratory, Division of Biology
BONNIE J. SPERFSLAGE
Kansas State University, Anti-Cancer Drug Laboratory, Division of Biology
CORBIN J. McILVAIN
Kansas State University, Anti-Cancer Drug Laboratory, Division of Biology
JEAN-PIERRE PERCHELLET
Kansas State University, Anti-Cancer Drug Laboratory, Division of Biology

JOURNAL FREE ACCESS

2002 Volume 55 Issue 2 Pages 181-190

DOI https://doi.org/10.7164/antibiotics.55.181

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Abstract

The synthesis and structural determination of a number of new rhodomycin derivatives, modified in the sugar part are described. The cytotoxicity against leukemic L1210 cells of these compounds is reported, along with β-rhodomycinone and two regioisomers of the above compounds, which were isolated during the synthetic procedure.

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