The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tü 6040
II. Structure Elucidation and Biosynthesis
MEIKE HOLZENKÄMPFERMARTINA WALKERAXEL ZEECKJUDITH SCHIMANAHANS-PETER FIEDLER
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2002 Volume 55 Issue 3 Pages 301-307

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Abstract

The simocyclinones D4 (1) and D8 (2), members of a novel class of antibiotics, were isolated from the mycelial extract of Streptomyces antibioticus Tü 6040 and consist of angucyclinone, deoxysugar, octatetraene dicarboxylate and aminocoumarin structural elements. The structure elucidation was done by one and two dimensional NMR experiments, and other spectroscopic methods in combination with incorporation experiments using 13C labelled precursors.

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