Novel Antifungal Diketopiperazine from Marine Fungus

HEE-GUK BYUN; HUIPING ZHANG; MASAMI MOCHIZUKI; KYOKO ADACHI; YOSHIKAZU SHIZURI; WON-JAE LEE; SE-KWON KIM

doi:10.7164/antibiotics.56.102

HEE-GUK BYUN, HUIPING ZHANG, MASAMI MOCHIZUKI, KYOKO ADACHI, YOSHIKAZU SHIZURI, WON-JAE LEE, SE-KWON KIM

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JOURNAL FREE ACCESS

2003 Volume 56 Issue 2 Pages 102-106

DOI https://doi.org/10.7164/antibiotics.56.102

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Abstract

Marine fungi producing antifungal compounds were screened against Pyricularia oryzae (P. oryzae), and a metabolite of marine fungus M-3 isolated from laver (Porphyra yezoensis) showed potent activity. Novel diketopiperazine (1) was isolated from the culture extracts, and its structure was elucidated by spectroscopic methods. The MIC of 1 against P. oryzae was 0.36μM.

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