FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No. 408813 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities of FR252921, FR252922 and FR256523

KIYOTAKA FUJINE; MIHO TANAKA; KEISUKE OHSUMI; MICHIZANE HASHIMOTO; SHIGEHIRO TAKASE; HIROTSUGU UEDA; MOTOHIRO HINO; TAKASHI FUJII

doi:10.7164/antibiotics.56.55

FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No. 408813

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities of FR252921, FR252922 and FR256523

KIYOTAKA FUJINE, MIHO TANAKA, KEISUKE OHSUMI, MICHIZANE HASHIMOTO, SHIGEHIRO TAKASE, HIROTSUGU UEDA, MOTOHIRO HINO, TAKASHI FUJII

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JOURNAL FREE ACCESS

2003 Volume 56 Issue 2 Pages 55-61

DOI https://doi.org/10.7164/antibiotics.56.55

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Abstract

Novel immunosuppressive agents, FR252921, FR252922 and FR256523 were isolated from the cultured broth of a bacterial strain No. 408813. The strain was identified Pseudomonas fluorescens from morphological and physiological characteristics.
FR252921, FR252922 and FR256523, novel compounds containing macrolactone ring, showed immunosuppressive activity against murine splenocyte proliferation stimulated with lipopolysaccharide (LPS) or anti-CD3 mAb in vitro.

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