The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
FR252921, a Novel Immunosuppressive Agent Isolated from Pseudomonas fluorescens No. 408813
I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities of FR252921, FR252922 and FR256523
KIYOTAKA FUJINEMIHO TANAKAKEISUKE OHSUMIMICHIZANE HASHIMOTOSHIGEHIRO TAKASEHIROTSUGU UEDAMOTOHIRO HINOTAKASHI FUJII
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2003 Volume 56 Issue 2 Pages 55-61

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Abstract
Novel immunosuppressive agents, FR252921, FR252922 and FR256523 were isolated from the cultured broth of a bacterial strain No. 408813. The strain was identified Pseudomonas fluorescens from morphological and physiological characteristics.
FR252921, FR252922 and FR256523, novel compounds containing macrolactone ring, showed immunosuppressive activity against murine splenocyte proliferation stimulated with lipopolysaccharide (LPS) or anti-CD3 mAb in vitro.
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© Japan Antibiotics Research Association
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