The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Synthesis and Structure-activity Relationship of Antifungal Coniothyriomycin Analogues
KARSTEN KROHNBRIGITTA ELSÄSSERSÁNDOR ANTUSKRISZTINA KÓNYAEBERHARD AMMERMANN
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2003 Volume 56 Issue 3 Pages 296-305

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Abstract

The structure of the antifungal metabolite coniothyriomycin was systematically modified by changing the acids of the open chain imide, modification of the hydrophobicity, variation in the degree of saturation, replacement of carbons by nitrogen or oxygen, and incorporation of the open chain molecule into cyclic arrangements. Structure-activity studies showed that antifungal activity was retained by replacement of phenylacetic acids by benzoic acids in the imide structure but diminished by hydrogenation of the fumaric ester part.

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