Gerfelin, a Novel Inhibitor of Geranylgeranyl Diphosphate Synthase from Beauveria felina QN22047

I. Taxonomy, Fermentation, Isolation, and Biological Activities

Abstract

A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C₁₅H₁₄O₆. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.