New Diketopiperazines from the Entomopathogenic Fungus Verticillium hemipterigenum BCC 1449

CHONGDEE NILANONTA; MASAHIKO ISAKA; PRASAT KITTAKOOP; JUNYA SAENBOONRUENG; VATCHARIN RUKACHAISIRIKUL; PALANGPON KONGSAEREE; YODHATHAI THEBTARANONTH

doi:10.7164/antibiotics.56.647

New Diketopiperazines from the Entomopathogenic Fungus Verticillium hemipterigenum BCC 1449

CHONGDEE NILANONTA, MASAHIKO ISAKA, PRASAT KITTAKOOP, JUNYA SAENBOONRUENG, VATCHARIN RUKACHAISIRIKUL, PALANGPON KONGSAEREE, YODHATHAI THEBTARANONTH

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JOURNAL FREE ACCESS

2003 Volume 56 Issue 7 Pages 647-651

DOI https://doi.org/10.7164/antibiotics.56.647

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Abstract

Two new diketopiperazines, bisdethiodi (methylthio)-1-demethylhyalodendrin and 1-demethylhyalodendrin tetrasulfide, together with two known cyclodepsipeptides, enniatins B and B₄, and two known pyrones, pyrenocines A and B, were isolated from a culture broth of the entomopathogenic fungus Verticillium hemipterigenum BCC 1449. These structures were elucidated using spectroscopic methods and X-ray crystallography. Antimalarial and cytotoxic activities of these compounds were evaluated.

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