The Journal of Antibiotics
Tripropeptins, Novel Antimicrobial Agents Produced by Lysobacter sp.
II. Structure Elucidation
HIDEKI HASHIZUMESEHEI HIROSAWARYUICHI SAWAYASUHIKO MURAOKADAISHIRO IKEDAHIROSHI NAGANAWAMASAYUKI IGARASHI
Author information
JOURNALS FREE ACCESS

Volume 57 (2004) Issue 1 Pages 52-58

Details
Abstract

Planar structures of tripropeptins (TPPs) were elucidated by spectroscopic studies including various NMR measurements. Stereochemistry of constituent amino acids of tripropeptin C (TPPC) (3) was identified by marfey's method except hydroxyproline which was determined by studies of NMR and CD spectra. The absolute structure of 3 was determined by analyses of the fragments obtained by Birch reduction and LiBH4 reduction of 3. The configuration of the fatty acid, isolated from acid hydrolysate of 3, was determined to be (3R)-hydroxy-13-methyltetradecanoic acid from MS, NMR spectra and negative sign of the optical rotation.

Information related to the author
© Japan Antibiotics Research Association
Previous article Next article

Recently visited articles
feedback
Top