Synthesis of Novel 26-Substituted Milbemycin A4 Derivatives and Their Acaricidal Activities

TAKAHIRO TSUKIYAMA; HISAKI KAJINO; YOSHIHISA TSUKAMOTO; HARUMI NAKAGAWA; TOSHIAKI YANAI; KAZUO SATO; SHINJI YOKOI; REIJI ICHINOSE; KEIJI TANAKA

doi:10.7164/antibiotics.57.446

Synthesis of Novel 26-Substituted Milbemycin A₄ Derivatives and Their Acaricidal Activities

TAKAHIRO TSUKIYAMA, HISAKI KAJINO, YOSHIHISA TSUKAMOTO, HARUMI NAKAGAWA, TOSHIAKI YANAI, KAZUO SATO, SHINJI YOKOI, REIJI ICHINOSE, KEIJI TANAKA

Author information

TAKAHIRO TSUKIYAMA
Agroscience Research Laboratories, Sankyo Co., Ltd.
HISAKI KAJINO
Process Development Laboratories, Sankyo. Co., Ltd.
YOSHIHISA TSUKAMOTO
Agroscience Research Laboratories, Sankyo Co., Ltd.
HARUMI NAKAGAWA
Agroscience Research Laboratories, Sankyo Co., Ltd.
TOSHIAKI YANAI
Agroscience Research Laboratories, Sankyo Co., Ltd.
KAZUO SATO
Intellectual Property Department, Sankyo Co., Ltd.
SHINJI YOKOI
Agroscience Research Laboratories, Sankyo Co., Ltd.
REIJI ICHINOSE
Crop Protection Department, Sankyo Agro Co., Ltd.
KEIJI TANAKA
Agroscience Research Laboratories, Sankyo Co., Ltd.

JOURNAL FREE ACCESS

2004 Volume 57 Issue 7 Pages 446-455

DOI https://doi.org/10.7164/antibiotics.57.446

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Abstract

A series of novel 26-substituted milbemycin A₄ derivatives was synthesized from 5-O-t-butyldimethylsilyl-26-hydroxymilbemycin A₄ prepared by selenium dioxide oxidation of 5-O-t-butyldimethylsilyl-milbemycin A₄. Their acaricidal activities were assessed against the organophosphorus-sensitive two-spotted spider mite (Tetranychus urticae) on the primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.

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