BACTERIOLOGICAL STUDY ON MINOCYCLINE,A NEW TETRACYCLINE DERIVATIVE

Abstract

Minocycline, a new tetracycline derivative, reported by MARTELL and BOOTHE, is a broad-spectrum antibiotic. It has 2-4 times stronger antibacterial activity against gram-positive cocci in vitro as compared with that of tetracycline. There is no cross resistance between minocycline and tetracycline or demethylchlortetracycline in clinically isolated strains, especially in Staphylococcus aureus and Streptococcus hemolyticus.
More prominent effect was also observed in therapeutic experiments of mice with experimental infections than tetracycline as observed in vitro.