Abstract
Some experiments on aminocyclohexyl-penicillin (AC-PC) were undertaken with the purpose of its clinical evaluation in the field of surgery, and the following results were obtained.
1)In vitro activity of AC-PC, antibacterial spectrum of which being similar with ampicillin (AB-PC), was weak and inferior to AB-PC.
2) The cross resistance with AB-PC and PC-G was proved to exist.
3) In the sensitivity distribution of Staphylococcus aureus isolated from infectious lesions, high resistant strains against AC-PC were somewhat less than against AB-PC and PC-G. According to the inactivation test by penicillinase, the stability of AC-PC to such enzyme, however, was only comparable with that of phenoxyethyl-penicillin, being stronger than AB-PC but weaker than PC-G. Such being the case, it is doubtful if this synthetic penicillin is of value as penicillinase resistant one.
4) Effective serum and urine concentrations of AC-PC, when it was administered orally in 500 mg as single dose, persisted four and six hours, respectively.
5) Though the excretion was mainly taken place renally, it also migrated into bile, concentration of which reaching 4 to 7 times higher than that of serum, and consequently its good distribution into organs such as kidneys and liver was observed.
6) Of twenty-two cases of minor surgical infection, to which AC-PC was given, 77 % was successfully treated.
7) Side effects complained of and noticed were mild and transient.
