DRUG ACTIVITY OF CAPREOMYCIN AND KANAMYCIN, OR VIOMYCIN AGAINST DRUG-RESISTANT TUBERCLE BACILLI ISOLATED FROM PULMONARY TUBERCULOUS IN-PATIENTS
1971 Volume 24 Issue 3 Pages 149-151
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1971 Volume 24 Issue 3 Pages 149-151
The drug activity of capreomycin (CPM) against kanamycin (KM) or viomycin (VM) resistant tubercle bacilli and the drug activity of KM or VM against CPM resistant tubercle bacilli were examined in vitro. Thirty strains tested were isolated from the in-patients affected with pulmonary tuberculosis. KIRCHNER agar containing 10% albumin was used for the examination.
(1) The strains resistant to KM or VM were not always susceptible to CPM, and the strains resistant to 100mcg/ml of KM or VM were less susceptible to CPM than the strains resistant to 10mcg/ml of KM or VM.
(2) The strains resistant to 10mcg/ml of CPM were susceptible to KM or VM. However, some of the strains resistant to 100mcg/ml of CPM showed decreased susceptibility to KM or VM.
