Abstract
Absorption, excretion and distribution of colistin sulfate (CLS) was examined in chickens and pigs.
(1) After oral administration of CLS in chicken, the serum and bile levels reached maximum of 10.2 and 5.7mcg potency/ml at 2 hours with a dose of 50mg potency/kg, and were greatly reduced after 6 hours. The concentration of CLS in other organs were lower or almost undetectable. With 25mg potency/kg, the concentration in organs were nil.
(2) In pigs, the serum and bile levels of CLS following oral administration were 1.0 and 4.0 mcg potency/ml with 25mg potency/kg, 8.3 and 9.0 mcg potency/ml with 50 mg potency/kg respectively. In other organs, the levels were lower or almost undetectable.
(3) When feeds containing 1, 3 and 9 ppm of CLS were given to pigs for 16 weeks, lower concentrations of CLS distributed in serum and bile, and almost undetecable levels in other organs.
