Abstract
Antibacterial activity of lividomycin (LVM) was investigated and the following results were obtained.
1. Antibacterial activity of LVM was almost the same as those of kanamycin (KM) and paromomycin (PRM) against Staphylococci and gram-negative bacteria including E.coli, Klebsiella, Proteus and Aerobacter.
2. Antibacterial activity of LVM against Pseudomonas aeruginosa was stronger than those of KM and PRM, and 85% of tested Pseudomonas was inhibited with 100mcg/ml of LVM.
3. Isolation frequencies of resistant mutants were not remarkably different between LVM and KM.
4. LVM was found to be cross resistant with KM in many strains isolated clinically. But some KM-resistant and LVM-sensitive strains were isolated.
5. Antibacterial activity of LVM was highest at pH 7.0 and reduced to one-fourth at pH 9.0.
