Abstract
Lividomycin (LVM), a new antibiotic produced by Streptomyces lividus have been known to show highly activities against gram-positive and -negative bacteria including Mycobacterium tuberculosis. The in vitro antituberculous activity of LVM was compared with other antituberculous agents and the following results were obtained.
1) The minimum inhibitory concentrations of LVM against M.tuberculosis H37Rv were 1.56mcg/ml in KIRCHNER's liquid medium, 0.39mcg/ml in Tween-albumin liquid medium and 3.13mcg/ml in KIRCHNER's agar medium.These MICs were almost similar to those of kanamycin (KM) and dihydrostreptomycin (SM) and were slightly lower than viomycin (VM) and capreomycin (CPM).
2) The antituberculous activity of LVM remarkably decreased in 1% OGAWA's medium.
3) The activity of LVM was not influenced by addition of 50% calf serum in KIRCHNER's liquid medium.
4) The MIC of LVM was varied by inoculum size, but this fluctuation was the same as that of KM and SM.
5) The resistance to LVM developed slower than KM.
6) There was strong cross-resistance between LVM and CPM, partial cross resistance between LVM and KM, but no cross resistance between LVM and SM or PAS.
