Abstract
Teratological effects of josamycin propionate on ICR-SLC mice and SD-SLC rats were studied, and the following results were obtained.
Josamycin propionate was administered orally at the daily dose of 200, 1,000 and 2,000mg/kg body weight for 7 days to pregnant mice of 7th-13th day of gestation and pregnant rats of 8th-14th day of gestation.
1) In mice, the increase in body weight was suppr essed in animals given 1,000 and 2,000mg/kg of the compound as compared with the control group.
2) A dose of 2,000mg/kg caused a marked increase in wet weight of the spleen in 3 out of 25 mother mice, and in these amimals the resorption rate of fetuses was 75%.
3) In growth of fetuses of mice and rats, no significant difference was observed between the control and the medicated group.
4) No teratological effect was observed on the fetuses of mice and rats.
