SUSCEPTIBILITY OF ANAEROBIC BACTERIA TO LINCOMYCIN AND CLINDAMYCIN

Abstract

The minimal inhibitory concentrations of about 200 clinical isolates of anaerobic bacteria to lincomycin (LCM) and clindamycin (CLDM) were determined by agar-dilution technique employing agar as basic medium and steel-wool method.
Many strains of Peptococcus, Peptostreptococcus and Veillonella were sensitive to the concentration of 6.25mcg/ml LCM and of 3.13mcg/ml CLDM, though one strain of Peptococcus prevotii was resistant to 100mcg/ml LCM and CLDM, and 5 strains of Peptococcus variabilis had no susceptibility to CLDM (100mcg/ml).
Many strains of Bacteroides were inhibited by 6.25 mcg/ml LCM as well as by 3.13mcg/ml CLDM.
Whereas Fusobacterium varium and F. glutinosum had low susceptibility to LCM and CLDM in comparison with Peptococcus, Peptostreptococcus, Veillonella and Bacteroides. Most of them were resistant to these drug at concentration of 25mcg/ml.
Antibacterial activity of CLDM against anaerobes tested in this study excelled erythromycin and rifampicin (RFP). LCM had less activity than RFP.