Abstract
1. The minimal inhibitory concentrations of clindamycin palmitate against 30 strains of Staphylococcus aureus were 0.36-0.2 mcg/ml.
2. Assays of the blood and aqueous humor levels after oral dose of 50 mg/kg of clindamycin palmitate were performed in rabbits. The peak of the blood level (3.4 mcg/ml) was reached in 1 hour and the aqueous humor level reached O.9mcg/ml in 2 hours.
3. Clindamycin palmitate was administered to children with acute infections at doses of 10-20mg/kg/day divided into 3 portions. By the treatment of clindamycin palmitate, 91.8% of these cases were improved.
4. Side effect such as exanthema and diarrhoea were observed in 3 of 37 patients treated with clindamycin palmitate.
