Abstract
The antimicrobial activity of paromomycin (Aminosidine)(PRM (AMD)) against tubercle bacilli was examined in vitro, and the susceptibility of kanamycin (KM), capreomycin (CPM) or viomycin (VM) resistant strains to PRM (AMD) was investigated. Fifty one strains in total tested were isolated from the in-patients affected with pulmonary tuberculosis. KIRCHNERag ar containing 10% albumin was used for the examination.
(1) The strains resistant to 10 mcg/ml of KM were susceptible to PRM (AMD). However, some of the strains resistant to 100 mcg/ml of KM showed decreased susceptibility to PRM (AMD).
(2) The strains resistant to CPM or VM were not always susceptible to PRM (AMD), and the strains resistant to 100 mcg/ml of CPM or VM were less susceptible to PRM (AMD) than the strains resistant to 10 mcg/ml of CPM or VM.
