Abstract
Amoxicillin granule (100mg AMPC potency per 1.0g granule) was administered to pediatric patients with the following results.
1) AMPC serum concentration and the urinary recovery of two preparations (Clamoxyl ‘Beecham’and Sawacillin ‘Fujisawa’) granule were compared in a cross over trial in 5 healthy adult volunteers. No significant difference in the results was observed between the two granules.
2) The peak serum concentration after oral administration of 10mg/kg AMPC to 5 children gave an average of 5.06μg/ml 1 hour after administration. The 6-hour urinary excretion was distributed 51.4-78.9%.
3) AMPC was administered at a dose of about 20mg/kg/day to 35 children with acute pediatric infections that is scarlet fever, acute tonsillitis, tonsillitis lacunalis, acute bronchitis, bronchial asthma +bronchitis and infectious impetigo. An effective therapeutic result was obtained in all cases.
4) The granule was well accepted by young children, and at a dose level of about 20mg/kg/day for a week no disorder on hepatorenal function was observed in any of the patients.
