Abstract
Neuromuscular blocking properties of tobramycin (Tobracin IP 60 mg), dibekacin (Panimycin® 100 mg) and ribostamycin (Vistamyciwit, 1g) were studied in man during anesthesia and surgery by observing the effects of these antibiotics on muscle twitch tension.
These antibiotics alone did not show any neuromuscular blocking action in the therapeutic doses. The neuromuscular blocking action of d-tubocurarine chloride was potentiated by the intravenous administration of 1g of ribostamycin. Tobramycin 60 mg did not show any remarkable effect, but dibekacin 100 mg produced a slight potentiating effect on the action of d-tubocurarine. The enhancement of the action of d-tubocurarine was antagonized by edrophonium and calcium. The action of succinylcholine chloride was not affected by tobramycin or ribostamycin, but it was potentiated transitorily by dibekacin.
It is advisable to pay attention to possible respiratory depression when ribostamycin and dibekacin are used in combination with non-depolarizing muscle relaxants and/or anesthetics.
