Abstract
Thirty-one patients who were performed thoracotomy for the disease of the chest, were administered sulfobenzyl penicillin 5.0g for an hour during their operation. Antibiotic levels of serum and intrathoracic tissues (a piece of lung parenchyma, pleura, pulmonary hilar lymphnode, fatty-tissue and chest wall muscle) were determined, and an evaluation of bactericidal effect was discussed.
In this study, we found that antibiotic levels of lung tissue with infectious or inflammatory disease were remarkably high compared with the levels of bronchogenic carcinoma. This means that a high concentration of sulfobenzyl penicillin to infectious intrathoracic tissues is effective against post-operative infection.
