Abstract
Effectso f fosfomycin-sodium (FOM-Nau) pon renal functions were studied with male rats.
1) After fasting for 24 hours, 25 ml/kg body weight of physiological saline were, orally administeerreeda fatnedr. reTspheec stuivbesleyq1 u6e0na nt udr i3n2a0tmi ogn/sk agm oof uFnOtsM a-tN 4a w hoeurers in tirnatperevriatlo wneearell dyae tdeMrmininisetde rtedi mmediatelyth o see no efFfeOcMtof- N a upon the urination amount.
2) After suspending, water supply for 2 days, 1,000 mg/kg of FOM-Na were intraperitoneally administered once a day for successive 2 days. On the 3rd day, 50ml/kg of dextran were intraperitonally administered, and one hour thereafter, 1,000mg/kgo f F ONT-Nwa ere intramuscularlya dministered to hind leg. Blood samples were collected the following day (suspension of water was con-ti nued until blood sample collection) to determine the BUN and UA in serum. FOM-Na wasf ound ekerting on reinforcing effect upon renal dysfunctions caused by dextran.
