Abstract
Tobramycin (TOB) concentration in the bone marrow of tibia was examined 1, 2, 3 and 4 hours after intramuscular injection of 60mg: TOB concentration in the bone marrow of tibia 1 hour after injection was 2.8±0.578μg/ml. Ratio to serum was 87.5%. TOB concentration in the bone marrow of tibia 2 hours after injection was 1.6±0.480μg/ml. Ratio to serum was 94.1%. TOB concentration in the bone marrow of tibia 3 hours after injection was 1.1±0.337μg/ml. Ratio to serum was 84.6%. TOB concentration in the bone marrow of tibia 4 hours after injection was 0.8±0.372μg/ml. Ratio to serum was 80.0%. Penetration capacity of TOB into the bone marrow of tibia was excellent.
