CLINICAL EFFECTS OF NK 631, A NEW BLEOMYCIN DERIVATIVE, IN TREATMENT OF ORAL CANCER

Abstract

We used only NK 631, a new bleomycin derivative, for 10 cases of primary oral cancer, and obtained following results.
(1) Anti-cancer effects were immediate and as follow: remarkably good in 1 case, efficacious in 8 cases, and none in 1 case.
(2) In clinical examination, peripheral blood, function of kidney, liver, etc. were normal. But attention must be payed to blood gas.
(3) Loss of hair, stomatitis and exanthema were noticed as side effects more clearly than regular bleomycin, but no fever.
As the result of the above, NK 631 is better than regular bleomycin in anti-cancer effect and activity, but more attention should be payed to the side effect.