Abstract
Cefuroxime (CXM), a new cephalosporin antibiotic, was used in pediatric field, and the following results were obtained.
1. Absorption and excretion
CXM was administered by intravenous drip infusion to 3 patients aged 14 years, 1 year and 1 month, and 5 years and 3 months, respectively, at doses of 15.4 mg/kg, 14.1 mg/kg, and 13.2 mg/kg. The following blood levels were obtained; 71pg/ml at the completion of infusion, 26.8μg/ml at 30 minutes, 13.2μg/ml at 1 hour, 5.05μg/ml at 2 hours, 2.07μg/ml at 4 hours, and <0.45μg/ml at 6 hours after the infusion. Urinary excretion of the drug administered was measured in one of these cases. The urinary excretion rate at 1-6 hours after intravenous drip infusion was 50.4%.
2. Clinical result
CXM 17-55mg/kg were administered for 2-4 days to 6 patients with acute respiratory tract infection, 1 with acute cervical lymphadenitis, and 1 with acute enteritis. The clinical result was poor in the case with acute enteritis and good in the other 7 cases. No side effect was observed in 9 cases (the above 8 cases plus 1 unassessable case), and the laboratory examination results showed no abnormality, either.
