Abstract
The authors have carried out the pharmacokinetics and clinical studies of CS-1170. The results were as follows; CS-1170 was given by drip infusion for 1 hour dose of 20 mg per kg body weight to 3 children. The maximum blood level was reached at one hour after drip infusion. This blood levels were 38μg/ml, 68μg/ml and 86μg/ml, respectively,(mean 64μg/ml), and level at 2 hours, 11.5μg/ml, 9.4μg/ml, 16μg/ml respectively,(mean 12.3μg/ml), the blood level at 6 hours was not determined.
The urinary excretion rates were 94.8-96.8% up to 6 hours after drip infusion dose of 20mg perkg body weight.
CS-1170 was effective in 7 of 8 cases with pediatric bacterial infections. An ineffective case was a pneumonia due to Serratia marcescens. No side effect was observed except for 2 cases with diarrhea and one case with elevation of GOT and GPT.
