1981 Volume 34 Issue 12 Pages 1588-1594
The clinical and pharmacokinetic studies of cefroxadine (CXD) dry syrup were conducted, and the following results were obtained.
1. A single dose of CXD either10mg/kg or20mg/kg was given to2patients each, and serum levels were peaked in the range of about 10 to 11 μg/ml.
2. About 30mg/kg of CXD per day was administered to 47infants and children (37;upper and lower respiratory tract infection, 3;urinary tract infection, 7; Others) aged from 6 months to 8 years and 1 month weighing 8 to 29kg, and a 97.8% (44 out of 45) of clinical response was obtained except for 2 cases whose efficacies were uncertain.
3. As the drug-induced side effects, only transient loose stool was observed in 2 cases. This, however, allowed to continue the treatment.
