CLINICAL STUDIES ON CEFROXADINE IN THE FIELD OF PEDIATRICS
1981 Volume 34 Issue 12 Pages 1604-1607
Details
1981 Volume 34 Issue 12 Pages 1604-1607
Cefroxadine dry syrup was administered to 57 children with acute febrile respiratory tract infections and 2 children with scarlet fever in the dose of 40mg/kg/day q. i. d. for 2-7 days.
65 strains of organism were isolated as pathogen from the 59 patients, and 50 of the 65 strains (76.9%) showed bacteriologically good response. Clinically, 55 children (93.2%) had good response.
Out of 63 strains isolated from the 57 cases with respiratory infections, 48 strains (76.2%) showed good bacteriological response.As for the type of pathogen, all strains of Staphylococcus aureus, 86.4% of Streptococcus haemolyticus and 90.0% of Streptococcus pneumoniae had good response, but as for Haemophilus influenzae it was only 47.6%.
In one child, Streptococcus pneumoniae appeared during cefroxadine treatment in addition to the preexisting Haemophilus influenzae. From the 4 children having no response for their respiratory infections, H. influenzae were isolated in 3 cases and Streptococcus haemolyticus was isolated in 1 case, before starting the treatment.
As for side effects, mild diarrhea developed in only 3 children.
