CLINICAL EVALUATION OF CEFROXADINE DRY SYRUP IN PEDIATRIC FIELD
1981 Volume 34 Issue 12 Pages 1626-1633
Details
1981 Volume 34 Issue 12 Pages 1626-1633
Clinical evaluation was carried out on cefroxadine dry syrup (containing 100mg of cefroxadine per 1g) for child use, and the following results were obtained.
1. Serum levels:
Peak serum levels at 1 hour after single administration of CXD 100mg (9.1mg/kg) to a 4-year old child (11kg) and 300mg (12.8mg/kg) to a 8-year old child (23.5kg) were 20.32μg/ml and 18.75 μg/ml, respectively.They declined to 0.78μg/ml and 0.88μg/ml respectively after 6hours and to undetectable levels after8hours.Half-life was1hour and 1.2 hours, respectively. CXD has shown the same concentration pattern as CEX, except for the fact that serum levels were peaked after 30 minutes and not detectable after 6 hours.
2. Clinical responses:
CXD was administered, for 7 days, to 33 children with scarlet fever in the dosage of _??_20-<60mg/kg/day (7childrenin _??_20-<30mg/kg/day, 21in _??_30-<40mg/kg/day and 5 in _??_40-<60mg/kg/day). Clinical responses were excellent in19cases and good in 14 cases, with an efficacy rate of 100%. All strains of group A Streptococcus is lated from the pharynx of 22 children were eradicated withln 24 hours. In 1 case each of acute pharyngitis, acute tonsillitis, acute laryngotracheitis and staphylococcal scalded skin syndrome, the dosage of _??_30-<45mg/kg/day produced a 100% good clinical response and eliminated the causative pathogens.
3. side effect:
Only 2 cases of eosinophilia were observed in hematologlc study as well as in hepatic and renal function tests before and after administration.
