Abstract
The absorption, excretion and influence on bowel flora of oral paromomycin sulfate (aminosidine, PRM) were studied in ten normal volunteers taking a normal diet, and the following results were obtained.
1. Serum levels of PRM were observed 0.46 μg/ml at a half hour, 1.14 μg/ml at 1 hour, 1.48 μg/ml at 2 hours, 0.70μg/ml at 4 hours, 0.29 μg/ml at 6 hours and were almost faded out at 12 hours after 4 grams of oral administration.
2. During 0-2 hours, 2-4 hours, 4-6 hours and 6-12 hours, the mean urine concentrations of PRM were observed 56.4 μg/ml, 56.2 μg/ml, 37.1 μg/ml and 13.8 μg/ml, respectively, and the total excretion in the urine by 12 hours were observed 21.14 mg (0.53%).
3. Oral administration of PRM caused fall in Lactobacillus, non spore-forming anaerobic Gram positive bacilli (BEP group) and Peptostreptococcus (P<0.001), Bacteroides (P<0.01). However, after administration was discontinued, reduced bowel flora was returned to the normal range within a few days.
No overgrowth of bowel flora by coliform, Clostridium or yeast was observed. Klebsiella oxytoca and toxigenic Clostridium difficile were not observed overgrowth.
4. No side effect was observed clinically over 2 months.
