Abstract
Serum and urinary levels of PIPC (sodium piperacillin) in patients with liver disease were investigated.
Serum and urinary levels of PIPC are affected by the degree of liver disease which is estimated most exactly by KICG, and it is available for determination of dose and administration interval.
When PIPC was administered intravenously at a dose of 2g, serum level in patients with liver disease was showed high and prolonged.Therefore this is convenient for PIPC of which biological half life is comparatively short.
In patients with serious liver cirrhosis, PIPC is probably cumulated by continuous administration and in this case, dose and administration interval will be needed to regulate.
