STUDIES ON9, 3-DIACETYLMIDECAMYCIN DRY SYRUP IN PEDIATRIC ACUTE RESPIRATORY TRACT INFECTIONS

Abstract

The authors have carried out some studies on MOM dry syrup in the field of pediatrics and the results were as follows.
1. After oral administration of MOM at20mg/kg, the serum level peaked at30minutes and MOM could still be detected in the serum at up to 4 hours.The half-life was0.67hour. The urinary recovery rate of MOM was1.43%up to6hours after this oral administration.
2. The clinical efficacy rates with MOM continuous treatment at a daily dose of19.4to50.0mg/kg (almost about30mg/kg) were85.7%for upper respiratory tract infections, 66.7%for lower respiratory tract infections and95.7%for Mycoplasma pneumonia.
3. It was easy to administer MOM orally even to the younger children. Although MOM was administered for4to21days, no side effects were observed locally or systemically except for transient slight diarrhea.
These results confirmed the usefulness of MOM in the treatment of acute respiratory tract infections in children.