Abstract
Ceftizoxime was tried in children with various infections and the following results were obtained.
1) Serum levels and urinary recovery of ceftizoxime were studied in 6 patients aged from 6 to 10 years.After intravenous bolus injection of 20 mg/kg, the mean serum concentrations were 113.9μg/ml, 47.6 g/ml, 31.8μg/ml, 18.5μg/ml, 6.3μg/ml and 2.1μg/ml at 5 minutes, 30minutes, 1 hour, 2 μ hours, 4 hours and 6 hours, respectively.The average urinary recovery rates of ceftizoxime were 55.1%, 90.9% and 98.3% at 2 hours, 4 hours and 6 hours after the administration, respectively.
2) The therapeutic efficacy was excellent in 11, good in 9 and poor in 2 patients, the efficacy rate being 91%.
3) As for the side effects, elevation of S-GOT and S-GPT, and drug fever were observed in 1case, but disappeared soon after discontinuation of the therapy.
