Cefsulodinの小児科領域における基礎的, 臨床的検討

秋田 博伸; 岩田 敏; 岩崎 由紀夫; 金光 岳文; 服部 春木; 城崎 慶治; 堀田 昌宏; 山下 直哉; 南里 清一郎; 砂川 慶介; 岩田 崇; 小佐 野満; 市橋 保雄

doi:10.11553/antibiotics1968b.35.2652

THE BASIC AND CLINICAL STUDIES ON CEFSULODIN IN PEDIATRIC FIELD

HIRONOBU AKITA, SATOSHI IWATA, YUKIO IWASAKI, TAKEFUMI KANEMITSU, HARUKI HATTORI, KEIJI JOZAKI, MASAHIRO HOTTA, NAOYA YAMASHITA, SEIICHIRO NANRI, KEISUKE SUNAGAWA, TAKASHI IWATA, MITSURU OSANO, YASUO ICHIHASHI

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HIRONOBU AKITA
Department of Pediatrics, School of Medicine, Keio University
SATOSHI IWATA
Department of Pediatrics, School of Medicine, Keio University
YUKIO IWASAKI
Department of Pediatrics, School of Medicine, Keio University
TAKEFUMI KANEMITSU
Department of Pediatrics, School of Medicine, Keio University
HARUKI HATTORI
Department of Pediatrics, School of Medicine, Keio University
KEIJI JOZAKI
Department of Pediatrics, School of Medicine, Keio University
MASAHIRO HOTTA
Department of Pediatrics, School of Medicine, Keio University
NAOYA YAMASHITA
Department of Pediatrics, School of Medicine, Keio University
SEIICHIRO NANRI
Department of Pediatrics, School of Medicine, Keio University
KEISUKE SUNAGAWA
Department of Pediatrics, School of Medicine, Keio University
TAKASHI IWATA
Department of Pediatrics, School of Medicine, Keio University
MITSURU OSANO
Department of Pediatrics, School of Medicine, Keio University
YASUO ICHIHASHI
Department of Pediatrics, School of Medicine, Keio University

JOURNAL FREE ACCESS

1982 Volume 35 Issue 11 Pages 2652-2656

DOI https://doi.org/10.11553/antibiotics1968b.35.2652

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Abstract

A new cephalosporin cefsulodin (CFS) was studied basically and clinically and the following results were obtained.
1.The serum levels of25mg/kg of CFS administered intravenously were39.5mcg/ml after30minutes, 22.6mcg/ml after1hour, 11.6mcg/ml after2hours, 6.0mcg/ml after4hours and2.1mcg/ml after6hours. The half life from serum was84minutes.
2.Clinical response on 4 cases of Pseudomonas aeruginosa infections were all good.
3.The slight elevations of GOT, GPT were observed by the drug administrations in1case. From the above results, CFS was effective drug to P.aeruginosa infections by intravenous administration of 25mg/kg of CFS.

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