Abstract
Normal mice acutely and chronically infected with the S-273 strain of T.gondii, were treated with acetylspiramycin (ASPM) alone, 8 mg/mouse/day, per os, or in combination with an immunopotentiator (CSP-II), 10 mg/mouse/day, intraperitoneally, or sulfamethopyrazine (SMPZ), 2mg/mouse/day, per os, for a period of 4 weeks.
In the acute cases, a 99.4% cyst reduction was obtained with ASPM alone and no cysts were seen in the brains of mice treated with ASPM in combination with CSP-II or SMPZ.The organisms were significantly eradicated in the brain and heart tissues of mice trated with ASPM alone or in combination with CSP-II or SMPZ as shown by subinoculation to normal mice and the negative latex hemagglutination titers of the recipient mice.
In the chronic cases, a cyst reduction of 52.4% was obtained with mice treated with ASPM in combination with ap-n.A cyst reduction of 34.6%, 32.9% and 20.8% was obtained in the ASPM alone, CSP-II alone and ASPM in combination with SMPZ treated groups, respectively.A comparative clearing of the organisms in the heart tissues of mice treated with ASPM in combination with CSP-Hwas obtained compared to the other treatment groups but not in the brains of all groups.
