Abstract
The tissue distribution of9, 3-diacetylmidecamycin (MOM) was studied in the pregnant rats and in the rats following repeated administration. After oral administration of MOM (200mg/kg) in the pregnant rats, the levels in the placenta and in the uterus were2-3times higher than that in the blood, however the levels in the amniotic fluid and in the fetus were1/10-1/20 of the blood levels. After the third administration of MOM in the first day (30mg/kg p.o./dose, 3times/day, 4-hour interval), the levels in the liver, kidney, lungs, spleen, salivary glands and thymus were1.5-12times higher than that in the blood;the level in the muscle was almost equal to that in the blood;and the levels in the brain were1/3-1/10of the blood level.The tissue distribution patterns after repeated administrations were found to be similar to those of the first day administrations.
