Abstract
In order to evaluate the efficacy of cefmetazole (CMZ) against osseous and articular infections fundamentally, the sensitivity of clinically isolated strains of Staphylococcus aureus to the drug and its concentration in serum and bone marrow of tibia were determined.
1.The clinically isolated strains of S.aureus was found to be sensitive to 0.78μg-6.25μg CMZ per milliliter when inoculated at106cells/ml and to0.78μg-12.5μg CMZ per milliliter when inoculated at108cells/ml.No strains were resistant to CMZ.
2.One gram of CMZ was injected intramascularly before operation.Blood samples were collected from the bone marrow and the vein and measured for the concentration of CMZ.The mean concentration in the bone marrow of tibia were30.5μg/ml, 16.8μg/ml and8.9μg/ml1, 2, and 3 hours later, respectively, and the mean transfer rate from serum to bone marrow was104.8, 92.8 and 101.1% respectively.
3.CMZ concentration in bone marrow of tibia attained following an intramuscular injection of 1g of CMZ were higher than the MIC values for most of the clinically isolated strains of S.aureus, suggesting the effectiveness of CMZ in clinical practice.
