STUDIES OF THE CONCENTRATION OF CEFOXITIN IN ORO-MAXILLARY TISSUES AND SERUM

Abstract

We studied cefoxitin (CFX) concentration of oro-maxillary tissues in rats and in18patients by means of bioassay method.In rats, the highest peak concentrations were observed in the gingiva and buccal mucosa followed by the tongue, submaxillary gland, lower jaw bone and the masseter muscle in the order listed.
In patients, the highest peak concentrations were observed in the maxillary sinus mucosa and peak concentrations in oro-maxillary tissues were froml/5to2/3of the corresponding serum concentrations. Further study is needed to elucidate the reason for the high peak CFX concentration in the maxillary sinus mucosa and the apparent delayed peak concentration in the salivary gland.