FUNDAMENTAL STUDY OF CEFOTIAM IN INTRATHORACIC TISSUE

Abstract

Seven patients who were performed thoracotomy for the disease of the chest, were administered cefotiam dihydrochloride 2.0 g for about an hour by intravenous drip infusion during their operation. Antibiotic levels of serum and intrathoracic tissues (a piece of lung parenchyma, parietal pleura, pulmonary hilar lymph node, chest wall muscle, pulmonary cyst and nerve) were determined, and an evaluation of bactericidal effect was discussed.
In this study, we found that antibiotic level of poor blood suppled lung, so called the destroyed lung was remarkably high.This means that a high concentration of cefotiam dihydrochloride to intrathoracic tissue is effective against postoperative infection.