Abstract
Netilmicin was administered to 1case of simple acute pyelonephritis and 21cases of complicated urinary tract infections, 22cases in total, and the effects were evaluated clinically.
Total clinical effects of netilmicin evaluated by the UTI standard for evaluation of drug effects showed 61.9%of clinical effectiveness in21cases, and the results are satisfactory because11cases out of21cases were catheterized.
The result was examined bacteriologically;the frequency of detection of particular strains among23strains clinically isolated from complicated urinary tract infections was that10strains of P.aeruginosa (43.5%), 3of S. marcescens (13.0%), and3of E.coli (13.0%), and the ratios of bacteriologically disappeared strains were70%, 33.3% and66.7%, respectively, and the overall disappearance ratio was73.9%.
The MIC's determined for17strains and disappearance of the bacteria were examined;when MIC was less than6.25mcg/ml, 10strains out of12disappeared, that is, 83% of disappearance was obtained.
When MIC was larger than100mcg/ml, 2strains out of5disappeared, that is, 40%of disappearance was obtained. Disappeared2strains of bacteria were isolated from patients who were not catheterized.
Neither subjective symptoms nor abnormal laboratory findings related to the drug were observed.
It may be said from these findings that netilmicin is an effective drug for urinary tract infections.
