MUSCLE IRRITATION STUDY ON T-1982

Abstract

The local irritation effect of T-1982 after the intramuscular injection into the musculus vastus lateralis was examined in rabbits.
T-1982 was dissolved by the way of clinical use and was injected singly into the musculus vastus lateralis. Then the degree of muscular injury at the time of 2 days and 7 days after the injection was judged from muscle weight ratio, gross local observation and histological observation.
The degree of muscular injury caused by T-1982 was compared with that of saline, 0.75% acetic acid and 6%acetic acid.
On the degree of muscular injury of T-1982 was almost equal to that of 0.75% acetic acid, but milder than 6% acetic acid.
From these, it was concluded that the local irritation effect of T-1982 was grade 3.