Abstract
Serum concentrations of dibekacin (DKB), sisomicin (SISO) and gentamicin (GM) were measured in 3 rabbits after intratracheal administration through the transtracheal teflon tube. The peak serum levels (average) were 106μg/ml (administrated 100mg DKB for injection), 148μg/ml (administrated 100mg DKB solution), 166μg/ml (administrated 100mg SISO solution) and 80μg/ml (administrated 80mg GM solution).
Serum concentrations and urine excretions of DKB were measured in 3 volunteers after aerosol administration using ultrasonic nebulizer.The peak serum levels (average) were 4.6μg/ml (administrated 100 mg DKB for in jection) and 3.1μg/ml (administrated 100mg DKB solution).The urine excretions (average) were 3.7mg and 4.3mg respectively during 6 hours.Before and after administration of DKB aerosol the spirogram and flow-volume curve were examined in the volunteers.But the examinations showed no changes.
Sputum concentrations were measured in 1 patient with chronic bronchobronchiolitis after administration of DKB aerosols using the ultrasonic nebulizer.The highest sputum concentration was acquired immediately after nebulization and the sputum levels decreased gradually while time passed.
Six patients with the lower respiratory tract infections were treated with DKB aerosol therapy and the utility rate was 80%.
