Abstract
Patients with bronchopulmonary infections were treated with cefoperazone (CPZ), and the serum and pleural effusion concentrations were determined after 2 g CPZ drip infusion.The following results were obtained:
1. Eight of 10 patients treated with CPZ responded with a significant clinical improvement.
2. Side effects were found in 4 cases; eruption in 1 case, fever and granulocytopenia in 1 case, elevation of GPT in 1 case, and thrombocytopenia in 1 case.But these side effects disappeared immediately after cessation of CPZ treatment.
3. Intravenous drip infusion of 2g CPZ yielded a peak serum concentration of 112.0-210.0μg/ml immediately after the end of drip infusion, and a peak pleural effusion concentration of 8.8-43.0μg/ml at 2-6 hours after the end of drip infusion.
4. The ratio of peak pleural effusion concentration to peak serum concentration was 4.4-26.9%.
