Abstract
To study concentrations in the gynecological organs, ceftazidime (CAZ) was given intravenously by one shot of 0.5g to 1 patient and of 1.0g to 10 patients who underwent simple hysterectomy because of uterine myoma.Also, clinical effect of the drug was studied in 3 cases.The levels of CAZ in sera in uterine artery and elbow vein, and tissue concentrations in various sites of the gynecological organs obtained during 50 to 425 minutes after administration were determined by the paper-disc method with P.mirabilis ATCC 21100 strain.
Concentrations of CAZ at 92 minutes after administration of 1.0g i.v. were 39.8mcg/ml in serum of uterine artery, 47.6mcg/ml in serum of elbow vein, 20.5mcg/g (tissue/serum ratio 0.43) in the ovary, 18.0mcg/g (0.38) in the fallopian tube, 16.1mcg/g (0.34) in the endometrium, 34.5 mcg/g (0.72) in the myometrium, 30.8mcg/g (0.65) in the uterine cervix, 36.4mcg/g (0.76) in the portio vaginalis and then gradually decreased time-dependently.Tissue concentrations were higher than those in serum in the endometrium, uterine cervix and portio vaginalis at 147 minutes after administration.CAZ concentrations of adipose tissue between 353 and 365 minutes after injection of 1.0g were lower than 0.8mcg/g.
The clinical responses to CAZ in intrapelvic infections were good in all cases.Slight elevation of total bilirubin, to 1.5mg/dl, was observed in a case.In the light of these clinical findings, CAZ appears to be a potent antibiotic effective in the clinical application.
