Abstract
Cefbuperazone (CBPZ), a new cephamycin antibiotic, was studied for the distribution in the genital organs and the excretion to the pelvic dead space exudate by bioassay, and the following results were obtained.
1. CBPZ was rapidly distributed into the various tissues by intravenous drip infusion of 0.5g and 1.0g for 1 hour. Those levels depended on serum levels and the ratios (tissue level/serum level) were about 15-25%.
2. Obvious dose response between 0.5g and 1.0g of CBPZ was recognized for serum levels as well as tissue levels.
3. Serum and tissue levels were respectively analyzed by two-and three-compartment open model. Consequently, the obtained simulation curve approximated to the observed results.
4. The simulation curve and pharmacokinetic parameters by one-compartment open model were ap-propriate for CBPZ levels in the pelvic dead space exudate.
