Abstract
Sisomicin sulfate (SISO) was used for the treatment of infections complicated by malignant diseases in 10 cases; 4 cases with suspicious sepsis, 2 with pneumonia, 2 with urinary tract infection, 1 with renal abscess and 1 with cholecystitis.
SISO was administered by intravenous drip infusion at daily dose from 100 to 150 mg for 6 to 12 days, con-comitantly with other antibiotics.
Clinical results were as follows; Good in 2, fair in 5, poor in 3 cases.
As to the side effects of SISO, cylindruria with aggravation of microscopic hematuria and elevations of GOT, GPT and Al-P were observed each one of them, respectively. The relationship to the SISO, however, was not clear.
In view of the above results, the drip infusion of SISO may be useful for the treatment of serious infection complicated by malignant diseases.
