1984 Volume 37 Issue 7 Pages 1428-1439
The results on pharmacological effects of MT-141 were as follows.
1. MT-141 did not exert effect on central nervous system in mice and rabbits but potentiated the anesthetic effect of thiopental at doses above 800mg/kg i. v.
2. MT-141 slightly raised a level of blood pressure in dogs and also caused a slight increase in the blood flow and heart rate when intravenously given more than 400mg/kg.
3. This compound did not affect the spontaneous contraction of isolated guinea pig atria and the blood vessels in perfused rabbit ears.
4. MT-141 did not significantly affect the spontaneous contraction and coronary flow in isolated hearts of guinea pig.
5. The body temperature was raised slightly by an injection of more than 400mg/kg of MT-141.
6. These results suggest that MT-141 does not possess specific effect on central nervous system but at a high dose slightly affects the autonomic nervous system such as blood pressure, body temperature, heart rate and blood flow in experimental animals.
