THE TRANSFER OF CEFMENOXIME INTO THE RETROPERITONEAL FLUID AFTER EXTENSIVE PANHYSTERECTOMY

Abstract

This study was to investigate the transfer of cefmenoxime (CMX) to the retroperitoneal fluid after extensive panhysterectomy.
Twenty-two cases were examined and they were divided into 2 groups, 10 with 1.0g and 12 with 2.0g bolus intravenous administration of CMX.
1. In 1.0g group, CMX concentration in the retroperitoneal fluid was observed 42.0±9.59μg/ml (Mean±S. D.) at 1 hour and thereafter decreased gradually, but it still remained 7.91±5.18μg/ml at 6 hours after the administration.
2. In 2.0g group, its concentration was 33.4±34.5μg/ml at 30 minutes and reached to the peak level of 45.1±24.6μg/ml at 1 hour and then declined slowly, but it remained 13.3±8.28μg/ml at 6 hours after the injection.
The results demonstrated sufficient transfer of CMX to the retroperitoneal fluid.