1984 Volume 37 Issue 9 Pages 1620-1624
Forty-three children and 4 adults with Campylobacter enteritis were studied in the treatment of fosfomycin (FOM). FOM was administered per orally in doses ranging from 50 to 100mg/kg/day for children and 3g/day for adults for 5 days. Main symptomes such as diarrhea and fever were disappeared within 2 days on the average.
Campylobacter jejuni in stool specimen disappeared within a week in 95% of these patients. The duration of main symptomes and the period of positive stool culture were evidently shortened in FOM-treated group compared with non-treated group. All of the isolated strains were sensitive to FOM by mono-concentration disk method. MIC50 of these strains remained between 1.56 and 3.13μg/ml. None of these MIC was beyond 12.5μg/ml.
